Diptoindonesin G( Dip G )

Catalog No. M10656 CAS No. 1190948-58-3

A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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50MG	1782	Get Quote
100MG	2250	Get Quote
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Biological Information

Product Name

Diptoindonesin G
Note

Research use only, not for human use.
Brief Description

A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells.
Description

A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ.
In Vitro

——
In Vivo

——
Synonyms

Dip G
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

Estrogen Receptor/ERR
Research Area

——
Indication

——

Chemical Information

CAS Number

1190948-58-3
Formula Weight

360.321
Molecular Formula

C21H12O6
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1C2=C3C(OC(C4=CC=C(O)C=C4)=C3C5=C1C(O)=CC(O)=C5)=CC(O)=C2
Chemical Name

4,7,9-trihydroxy-1-(4-hydroxyphenyl)-6H-anthra[1,9-bc]furan-6-one

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Zhao Z, et al. Chem Biol. 2015 Dec 17;22(12):1608-21. 2. Juliawaty LD, et al. Nat Prod Commun. 2009 Jul; 4(7):947-50. 3. Gao J, et al. Cell Death Dis. 2017 May 4;8(5):e2765.

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